We have developed a novel structure-based evaluation for missense variants that explicitly models protein structure and amino acid properties to predict the likelihood that a variant disrupts protein function. A structural disruption score (SDS) is introduced as a measure to depict the likelihood that a case variant is functional. The score is constructed using characteristics that di... https://www.roneverhart.com/Apple-11-inch-iPad-Pro-Wi-Fi-64GB-Space-Gray-2018-release/