Abstract Intra-tumoral epigenetic heterogeneity is an indicator of tumor population fitness and is linked to the deregulation of transcription. However. there is no published computational tool to automate the measurement of intra-tumoral epigenetic allelic heterogeneity. We developed an R/Bioconductor package. https://www.spidertattooz.com/The-GelBottle-Inc-BIAB-Gel-Polish-Spirited-67oz-p17706/